Photoactivatable senolysis
Web谷粉学术论坛提供了文献求助板块,助力于帮助需要求助外文文献及疑难文献的网友, WebPhotoactivatable senolysis with single-cell resolution delays aging Nature Aging - Shi, Liu, Gao et al. present a strategy to monitor and selectively eliminate senescent cells in mice during aging through controllable photodynamic therapy, which inhibited the...
Photoactivatable senolysis
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WebA senolytic (from the words senescence and -lytic, "destroying") is among a class of small molecules under basic research to determine if they can selectively induce death of … WebMar 10, 2024 · Photoactivatable senolysis with single-cell resolution delays aging + A senolytic strategy integrating multiple technologies delays aging (research briefing) Senolytics have been shown to promote longevity but precise and trackable senolysis is still a challenge. An interesting approach to tackle this is described here - a photosensitive ...
WebFeb 4, 2024 · Log in. Sign up WebOct 27, 2024 · Photoactivatable senolysis with single-cell resolution reverses aging: Organism: Mus musculus: Experiment type: Expression profiling by high throughput …
WebDec 1, 2024 · The selective removal of senescent cells (SnCs), termed 'senolysis', can alleviate these age-related features and extend the healthy lifespan, as supported by … Our main focus in designing this senolytic prodrug was ensuring the accurate delivery of the photosensitive drug to SnCs for precise and controllable yet complete senolysis with single-cell resolution. We then report a prodrug strategy to design a photosensitive senolytic agent activated by SA-β-gal, an enzyme … See more The fluorescence spectra and the absorption spectra of KSL0608-O and KSL0608-Se were evaluated. Escherichia coli β-gal (E. coli β-gal), as the SA-β-gal model … See more We then examined the ability of KSL0608-O and KSL0608-Se to convert oxygen into reactive oxygen species (ROS) after photoirradiation using a commercial ROS … See more Before cell imaging, the cytotoxicity of our compounds was evaluated, and both compounds exhibited low cytotoxicity (Supplementary Fig. 2). Human ovarian cancer … See more Senescent MRC-5 cells at passage 40 (P40) were co-incubated with KSL0608-O or KSL0608-Se and commercial staining dyes targeting different organelles. The NIR … See more
WebJan 15, 2024 · Inhibition of KGA-dependent glutaminolysis in aged mice eliminated senescent cells specifically and ameliorated age-associated organ dysfunction. Our …
WebShi, D. et al. Photoactivatable senolysis with single-cell resolution delays aging. Nat. ... Se-mediated PDT achieves precise senolysis. This work was completed over three years, … green onion and cheddar biscuitsWebA strategy to monitor and selectively eliminate senescent cells in mice during aging through controllable photodynamic therapy, which inhibited the age-related functional decline and countered age-induced losses in liver and renal function. Strategies that can selectively eliminate senescent cells (SnCs), namely senolytics, have been shown to promote healthy … flynama reviewsWebReference: Photoactivatable senolysis with single-cell resolution delays aging. Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo. Citing article. flynaec.orgWebPhotoactivatable senolysis with single-cell resolution delays aging. / Shi, Donglei; Liu, Wenwen; Gao, Ying et al. In: Nature Aging, 02.02.2024. Research output: Contribution to … fly my wishWebMay 7, 2015 · Icosahedral viruses were the first biological assemblies whose structures were determined at near-atomic resolution using cryo–electron microscopy (cryo-EM) combined with methods for image averaging (1–10 11–20), the 465-kD Escherichia coli). There is great potential for the use of cryo-EM methods in applications such as drug … green onion and cornbread stuffingfly namibia booking onlineWebJan 15, 2024 · These findings have led to the exploration of pharmacological approaches to induce selective death in senescent cells (senolysis). Although it has been found that … flynama faucet reviews