Web30 de mai. de 2024 · e18513 Background: FN is an anticipated complication of consolidation with HiDAC for AML, though precise descriptions of incidence, type, and severity of … Web13 de nov. de 2024 · In the control arm A, patients receive an alternating R-CHOP/R-DHAP induction followed by myeloablative consolidation (either BEAM or THAM: TBI, high dose Ara-C and melphalan). In arm A+I Ibrutinib is added to the R-CHOP cycles (560 mg day 1-19) and applied as maintenance (continuous dosing) for 2 years.
Polygenic Ara-C Response Score Identifies Pediatric Patients With …
WebR-HDAC, or R-HD-AraC (ituximab plus (H)igh (D)ose ra-) is a chemotherapy regimen that is used, alternating with R-Maxi-CHOP, as part of so-called "Nordic protocol" of treating mantle cell lymphoma.It consists of monoclonal antibody rituximab and high-dose antimetabolite cytarabine.. High-dose Ara-C (HDAC) without rituximab also has several other uses in … WebAn understanding of the cellular pharmacology, cytokinetics and pharmacokinetics of ara-C in leukemic mice showed substantial schedule-dependency. Exposure to high doses for a short duration (C × t) resulted in a palliative therapeutic outcome. In marked contrast, exposure to lower doses for a protracted period (c × T) was curative. human interest story articles
Triangle: Autologous Transplantation after a Rituximab/Ibrutinib/ara-c …
Web1 de dez. de 2015 · Since May 1986, we have treated 98 patients with acute myeloid leukemia (AML) on a protocol consisting of induction with mitoxantrone (10 mg/m2) for 4 days and cytosine arabinoside (Ara-C) (100 mg ... Web1 de jun. de 1997 · Ara-C was administered at a dose of 3 g/m 2 every 12 h by 2-h intravenous infusion on days 1–4 (8 doses) and mitoxantrone at a dose of 6 mg/m 2 /day on days 1–5 (5 doses). Granulocyte colony-stimulating factor (G-CSF) was administered at a dose of 300 µg/day by subcutaneous injection when patients' WBC was <1000/µl for … WebCytarabine, also known as cytosine arabinoside (ara-C), is a chemotherapy medication used to treat acute myeloid leukemia ... Rarely, myelopathy has been reported after high … human-interest story meaning