Hif atf4
Weboverall protein synthesis. 25 This response is HIF-independent as both HIF-1α+/+ and HIF-1 α-/ MEFs respond similarly by phosphorylating eIF2α under hypoxic conditions. Since the oxygen availability within tumors fluctuates, multiple oxygen concentrations were used in vitro to assess the phosphorylation status of eIF2α. Indeed, at mild and Web15 de nov. de 2007 · Köditz et al describe the interaction of activating transcription factor-4 (ATF4) with the HIF hydroxylase PHD3, suggesting that oxygen-dependent regulatory pathways mediated by PHDs might not be ...
Hif atf4
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WebActivating transcription factor 4 (ATF4) is a critical transcription factor for bone remodeling; however, its role in bone angiogenesis has not been established. Here we show that … Web14 de abr. de 2024 · The expression of HK2 is controlled by major signaling pathways including the PI3K/Akt/HIF-1α axis and β-catenin/c-Myc signaling along with the transcription factor STAT3 and miR-199a [21,22,23,24].
WebRecent studies have shown that ATF4 can interact directly with some HIF-PHD isoforms and that ATF4 has phylogenetically conserved prolines (P156, P162, P164, P167, and P174) … Web21 de mai. de 2024 · Instead, we performed mechanistic studies in a classical model of neuronal ferroptosis and correlated adaptaquin's protective effects with its ability to suppress ATF4-dependent transcription (Figure 6 B), not with its ability to enhance HIF-dependent transcription (Aminova et al., 2005, Karuppagounder et al., 2016, Lange et al., 2008, …
WebWhile the hypoxia-inducible factors HIF-1 and HIF-2 are critical to the cellular response to hypoxia, HIF-independent processes are known to contribute to this adaptation. Recent … Web5 de mai. de 2016 · As ATF4 has been shown to correlate with oxidative stress 38, 39 and also to regulate and interact with HIF-PHDs, 40, 41 we examined the expression of ATF4 upon glutamate exposure to further ...
Web另一种转录因子 NRF2诱导 ATF4 激活非小细胞肺癌细胞 PHGDH和 PSAT1的表达[22]。此外， HIF－1和 HIF－2转录因子在乳腺癌细胞系缺氧条件下均 能诱导 PHGDH、PSAT1和 PSPH表达。
WebThe molecular mechanisms mediating nociception are unclear. Here, the authors show that the Activating Transcription Factor 4 (ATF4) is important for the response to heat … css noctuaggWebThe molecular mechanisms mediating nociception are unclear. Here, the authors show that the Activating Transcription Factor 4 (ATF4) is important for the response to heat nociception in mice and ... css no childrenWeb22 de mar. de 2024 · As VEGF expression was unaffected by HIF-1α deletion or PGC-1α overexpression following M and C deprivation, Longchamp et al. explored other … css no child selectorWeb1 de mar. de 2004 · Hypoxia is a key factor in tumor development, contributing to angiogenesis and radiotherapy resistance. Hypoxia-inducible factor-1 (HIF-1) is a major … earlsdon parkWeb[1]pkm2在肿瘤代谢中的作用和转化研究 《肿瘤药学》 2024 年 12卷 3期 [2]m2型丙酮酸激酶在肿瘤形成中的作用 《医学综述》 2024 年 24卷 19期 [3]atf4过表达对hepg2细胞凋亡的影响及其机制 《中国医药导报》 2024 年 15卷 19期 [4]胃癌bgc-823细胞中hif-1α、hif-2α对pkm2的调控作用 《实用药物与临床》 2024 年 20卷 4期 css niles ohioWeb10 de dez. de 2011 · To analyze the region of ATF4 required for the interaction with PHD1, we constructed several deletion mutants based on its reported domain structure (Fig. 2 … earlsdon park car parkWebNational Center for Biotechnology Information earlsdon post office phone number