Gwas fatty liver
WebApr 10, 2024 · Membrane bound O-acyltransferase 7 (Mboat7) encodes a phospholipid synthetic enzyme identified through genome-wide association studies (GWAS). 7, 8 To measure the degree to which liver-wide Mboat7 deletion promotes fatty liver disease, we used a high dose of adeno-associated virus serotype 8 (AAV8)-TBG-Cre to generate … WebJul 19, 2013 · Non-alcoholic fatty liver disease (NAFLD) is a common liver disease; the histological spectrum of which ranges from steatosis to steatohepatitis. Nonalcoholic …
Gwas fatty liver
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WebMay 19, 2024 · Nonalcoholic fatty liver disease (NAFLD) is supposed to manifest its metabolic phenotype in the liver, but it is common to have lean individuals diagnosed with NAFLD, known as lean NAFLD. ... GWAS of … WebFeb 21, 2024 · Background Although genetic features vary across ethnicities, few genome-wide association studies (GWAS) have reported the genetic determinants of liver enzyme expression. This study was aimed to evaluate the associations of genome-wide single nuclear polymorphisms (SNPs) with the liver enzymes in a Korean population. Methods …
WebMar 30, 2024 · For the primary outcome, summary genetic association data were extracted from a GWAS meta-analysis of four cohorts of electronic health record-documented NAFLD with participants of European ancestry including 8434 cases with hepatic steatosis, NASH, or liver fibrosis and 770,180 controls. 28 It is the largest GWAS dataset for analyses of ... WebNov 3, 2024 · To gain insight into the genetic architecture of non-alcoholic fatty liver disease (NAFLD), Ghodsian et al. performed a genome-wide meta-analysis of electronic health record-documented NAFLD and identify 7 potential susceptibility loci for this disease (located at or near GCKR, TR1B1, LPL, FTO, MAU2/TM6SF2, APOE, and PNPLA3).
WebDec 30, 2024 · Nonalcoholic fatty liver disease (NAFLD) is a common liver disease with a wide spectrum of liver conditions ranging from hepatic steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. ... The first reported GWAS study of NAFLD patients was in 2008 in a multi-cohort of Hispanics, … WebSep 1, 2024 · Lay summary. Non-alcoholic fatty liver disease is a common disease where excessive fat accumulates in the liver and may result in cirrhosis. To understand who is …
WebNon-alcoholic fatty liver disease (NAFLD) is a complex disease associated with premature mortality. Its diagnosis is challenging, and the identification of biomarkers causally …
WebApr 11, 2024 · HIGHLIGHTS. who: Yajing Tan from the Shandong First Medical University, China have published the research: Identification of shared genetic architecture between non-alcoholic fatty liver disease and type 2 diabetes: A genome-wide analysis, in the Journal: (JOURNAL) what: It is essential to note that this study cannot avoid the … how can i track my passport with tracking idWebMar 22, 2024 · Background: The incidence of complications of non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D) has been increasing. Method: In order to identify the shared genetic architecture of the two disease phenotypes of NAFLD and T2D, a European population-based GWAS summary and a cross-trait meta-analysis was used … how many people have colour blindnessWebMay 7, 2024 · Background & Aims Genome-wide association studies (GWAS) have identified several risk loci for non-alcoholic fatty liver disease (NAFLD). Previous studies … how can i track my passport renewal