Cthrc1 fibrosis
WebAbstract Pulmonary fibrosis (PF) is a heterogeneous disease with a poor prognosis. Therefore, identifying additional therapeutic modalities is required to improve outcome. ... collagen triple helix repeat containing 1 (CTHRC1), claudin 2 (CLDN2), latent transforming growth factor beta binding protein 2 (LTBP2) were proven to involve disease ... WebNov 11, 2024 · Lung fibrosis also progressed rapidly in this subset of NR-COVID-19 patients, where the development of lung injury to a state that a lung transplant was required for survival took 119 days ... Transcript …
Cthrc1 fibrosis
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WebApr 10, 2024 · We recently reported that DT-109 administered orally to mice at 500 mg/kg/day potently reduced steatohepatitis and fibrosis induced by a high-fat, -fructose, and -cholesterol diet (NASH diet). 13 To determine optimal dosing, we evaluated the dose response of DT-109 during NASH. C57BL/6J mice were fed the NASH diet for 12 weeks … WebFibrosis is mainly triggered by inflammation in various tissues, such as heart and liver tissues, and eventually leads to their subsequent dysfunction. Fibrosis is characterized by the excessive accumulation of extracellular matrix proteins (e.g., collagens) produced by myofibroblasts. The well-developed actin cytoskeleton of myofibroblasts, one of the main …
WebAug 1, 2015 · Collagen triple helix repeat containing-1 (Cthrc1) is a documented specific inhibitor of TGF-β signaling. Based on this observation, we developed the hypothesis that knocking in/knocking out the Cthrc1 gene in murine models of cholestasis would alter the natural history of cholestatic fibrosis. WebJan 11, 2024 · We demonstrated that CTHRC1 is a new regulator of liver fibrosis by modulating TGF-β signaling. Targeting CTHRC1 could be a promising therapeutic approach, which can suppress TGF-β signaling …
WebDec 29, 2024 · Keloid may induce severe impairment of life quality for the patients, although keloid is a cutaneous benign tumor. Collagen triple helix repeat containing protein 1 (Cthrc1) was identified as a novel gene that was originally found in adventitial fibroblasts after arterial injury. To address the role of Cthrc1 in keloid, the expression level of Cthrc1 was … WebMar 1, 2024 · Comprehensive single-cell analysis and RNA-Seq revealed that the expression of collagen triple helix repeat containing 1 (Cthrc1), a fibrosis …
WebAug 7, 2024 · Fibroblasts also have important pathophysiological and pathological functions, e.g., in wound contraction and tissue fibrosis 5,6,7. ... (marked also by C1qtnf3 and Cthrc1) ...
WebSep 25, 2024 · To determine whether cluster B can be identified in other models of cardiac fibrosis, we examined the presence of CTHRC1 + CFs in a model of chronic cardiac … cumberland campus gymWebDec 8, 2024 · Fibrosis is characterized by fibroblast dysfunction and excessive deposition of cell‐matrix that affect the normal functioning of the original tissue or organ. 1 The … eastpoint mall cell phone machineWebTreatment of cholestatic fibrosis by altering gene expression of Cthrc1: Implications for autoimmune and non-autoimmune liver disease Author links open overlay panel Zhaolian Bian a 1 , Qi Miao a 1 , Wei Zhong a 1 , Haiyan Zhang a , Qixia Wang a , Yanshen Peng a , Xiaoyu Chen a , Canjie Guo a , Li Shen a , Fan Yang a , Jie Xu a , Dekai Qiu a ... cumberland cams loginWebCollagen triple helix repeat containing 1 (CTHRC1), a glycoprotein, is involved in multiple pathological processes, including inflammation and fibrosis. However, the function of CTHRC1 in asthma ... cumberland cafeWebFeb 22, 2007 · We identified collagen triple helix repeat containing-1 (Cthrc1) ... G. Normal and pathologic soft tissue remodeling: role of the myofibroblast, with special emphasis on liver and kidney fibrosis. Lab Invest. 2003; 83: 1689–1707. Crossref Medline Google Scholar; cumberland canvas instructureWebFeb 22, 2007 · We identified collagen triple helix repeat containing-1 ... The rationale for this study was based on the facts that (1) constrictive arterial remodeling with vascular … east point market placeWebDec 23, 2004 · Collagen triple helix repeat containing 1 (Cthrc1) was identified in a screen for differentially expressed sequences in balloon-injured versus normal arteries. Cthrc1 expression was not detectable in … cumberland campground map