WebThe same SOX proteins also regulate γ-crystallin genes. the mammalian counterpart of δ crystallin. A conserved and essential DNA motif in the promoters of the γ-crystallin genes is the binding site of the SOX proteins that activate the promoters (Kamachi et al., 1995). SOX1 strongly, and SOX2 and SOX3 modestly, activate these crystallin ... WebThe two paralogous zebrafish αB-crystallin promoters produced subtly different expression profiles, with the aBa promoter driving expression equally in notochord and skeletal muscle while the αBb promoter resulted primarily in skeletal muscle expression.
Perturbed development of the mouse lens by polyomavirus large …
WebDec 1, 2012 · In many crystallin gene promoters, elements for lens and non-lens expression are combined in the same 5 ′ region. However, one of the more recently … WebThis study concluded that there existed a TGF-β responsive element in the promoter just 285 base pairs upstream of the transcriptional start site ... porcine TGF-β1 under the lens-specific αA-crystallin promoter and then another similar line was created but with the gene driven by the βb-crystallin promoter, corresponding to another lens ... razor wire steel cage match
The zebrafish as a model system for analyzing mammalian and …
WebMar 1, 1989 · Recently Landel et al. (1988) have combined the α -crystallin promoter with the ricin cytotoxic gene to produce a single line of transgenic mice with a somewhat more severe phenotype consisting of a still smaller lens and other interesting eye malformations. WebBy use of a gene fusion of the alpha A-crystallin promoter to the viral immortalizing oncogene, polyoma large T antigen (PyLT), we created transgenic mice that express PyLT specifically in ocular lens. Expression of large T antigen during embryonic development led to a perturbation in lens development, specifically, an interference with the ... WebMay 4, 2006 · Dramatic upregulation of αA-crystallin expression is associated with primary lens fiber cell differentiation. Previous studies have shown that a −366 to +46 αA … sims 100 baby challenge game