WebNov 7, 2024 · One of the main limitations to the Pt-therapy in cancer is the development of associated drug resistance that can be associated with a significant reduction of the … WebDec 15, 2024 · Findings showed the optimum swelling rate was 4903.876%. Then, the loading and release of cisplatin, selected as the hydrogel structure model drug, were …
A Multicompartment Human Kidney Proximal Tubule-on-a …
WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … WebOct 7, 2002 · We have also found that cisplatin reduced uptake of 64 Cu into wild-type cells; when treated for 2 h with 1 mM cisplatin, the level of 64 Cu uptake was 16% of that of … how to stop bad habits in dogs
Cisplatin (Cisplatin Injection): Uses, Dosage, Side Effects ... - RxList
WebJul 31, 2014 · A, degree of nephrotoxicity based on histology scores observed in kidneys isolated from wild-type (WT; n = 30), and Oct1/2 −/− (mice n = 18) 72 hours after administration of cisplatin. Toxicity scores are based on percentage of damaged tubules: 0 (<10%, absent), 1 (11%–25%, minimal), 2 (26%–50%, mild), 3 (51%–75%, moderate), … WebJan 11, 2024 · Studies in cells also showed that cisplatin can be taken up by passive diffusion mechanisms since its accumulation by concentration gradient up to its saturation point was not the rate limiting factor ( … WebApr 14, 2024 · The investigations demonstrated different impacts of cisplatin on CTR1 expression on the single-cell level according to the resistance status. The study showed this interrelation for the first time at the single-cell level. It could be shown in this study that the resistant ovarian cancer cells as compared to the sensitive cells are ... how to stop bad leg cramps at night