Cisplatin excretion

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August undefined, 2024

WebSep 15, 2024 · It is therefore not limited to elucidating the effects of drugs on organisms and cell cultures etc., but also includes its application for tracing a drug and its metabolites, from entry into the body to excretion. We also wish to examine applications that investigate the re-emerging role of the gut microbiota in these processes. WebApr 12, 2024 · Cisplatin is a platinum-based chemotherapy agent that currently used as front-line therapy in the treatment of various solid organ cancers, including head and neck, lung, testis, ovary, breast, bladder cancer and sarcoma [1–7]. The therapeutic effects of cisplatin are significantly improved by dose escalation.

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WebAim: Cisplatin (CP) induced acute renal failure (ARF) has previously been associated with decreased urinary prostaglandin E2 (PGE2) excretion and reduced aquaporin 2 (AQP2) expression in kidney collecting duct. WebOct 13, 2024 · Cisplatin is mainly cleared by the kidney through glomerular filtration and tubular excretion, resulting in a higher concentration of this drug in the kidney than in other organs. Renal... phim golden fish

DRUG NAME: Cisplatin - BC Cancer

WebCisplatin (90 mg/m2) was administered in a 5-minute bolus IV infusion to dogs at 8 AM (n = 6) or 4 PM (n = 6). Blood and urine samples were collected over a 4-hour period for statistical moment pharmacokinetic analysis. http://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf WebFeb 28, 2024 · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In … phim gods of egypt

Cisplatin: Uses, Interactions, Mechanism of Action

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Webcisplatin (r=0.48, P<0.05). Microalbuminuria was noted in 4 patients. Hypomagnesemia was present in 4 and hy-percalciuria in 3 patients; renal excretion of P, Mg, and uric acid was higher in patients than in controls. Glomer-ular function was not significantly altered and only mild tubular dysfunction was present. Since renal excretion of WebMar 2, 2024 · A single exposure to cisplatin resulted in intrinsic repair, with preserved tubular architecture and up-regulation of genes associated with homology-directed repair, including Fanconi anemia complementation group D2 (FANCD2). tslb application onlineWebDec 26, 2024 · Increased excretion of phosphate occurs primarily in the renal system. The proximal renal tubule reabsorbs up to 70% of filtered phosphate normally, and the distal tubule reabsorbs up to 15% of filtered phosphate. ... cisplatin, or pamidronate, current treatment for diabetic ketoacidosis, and any hospitalization requiring an Intensive care … phim gods and kings

"WebThese effects are due to renal tubular damage. Cisplatin greatly increases the urinary excretion of magnesium and calcium; increased excretion of potassium, zinc, copper … " - Cisplatin excretion

Cisplatin excretion

Cisplatin based chemotherapy in testicular cancer patients

WebFeb 17, 2024 · Cisplatin can cause dose-related peripheral neuropathy that becomes more severe with repeated courses of the drug. Dosage Forms Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Solution, Intravenous [preservative free]: WebÀ la suite d'un diagnostic de cancer de l'ovaire, la prise en charge thérapeutique constitue une étape déterminante dans la survie des patientes atteintes. Actuellement, la plupart de celles-ci subiront une cytochirurgie suivie d'une chimiothérapie standard comprenant du Cisplatin (ou Carboplatin) et du Paclitaxel. Malgré une réponse initiale adéquate, il a été …

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WebJan 12, 2024 · Since cisplatin resistance was generally associated with increased cisplatin export , we first analyzed the expression profile of genes annotated to regulation of cell excretion in a dataset GSE15120 from the GEO. The dataset comprises six pairs of parental and cisplatin-resistant HeLa cells. WebApr 24, 2024 · The mean cisplatin excretion was 70.3 ± 64.4, 7.3 ± 6.3, and 5 ± 4 μg/mg creatinine at 0-12, 12-24, and 24-48 h, respectively. Statistical analysis showed that the …

WebSep 20, 1996 · Cisplatin based chemotherapy in testicular cancer patients: long term platinum excretion and clinical effects Patients with advanced testicular cancer (TC) have a very good long-term prognosis owing to cisplatin-based polychemotherapy. Platinum is believed to be excreted at a rapid rate via urine within weeks after chemotherapy. WebCisplatin, a platinum-based chemotherapy agent, is commonly used in treating cancers that may affect women of childbearing age, including cervical cancer, triple-negative breast cancer, and pediatric tumors in adolescents.

WebExcretion rates for selected cytotoxic agents Cytotoxic agent Excretion rate Duration after therapy for which PPE is recommended when handling excreta* 5-Fluorouracil Urine: unchanged up to 15% over 24 Hours Urine: 2 Days Faeces: 5 Days Bleomycin Urine: … WebApr 24, 2024 · The maximum excretion of cisplatin was observed 0–12 h after chemotherapy and the amount of cisplatin excreted could not be used to predict ADRs. Other pharmacokinetic and genetic parameters should …

WebJun 1, 2024 · The recommended dosage of Gemcitabine for injection is 1250 mg/m 2 intravenously over 30 minutes on Days 1 and 8 of each 21-day cycle in combination with cisplatin 100 mg/m 2 administered intravenously on Day 1 after Gemcitabine for injection administration. Refer to cisplatin prescribing information for additional information. …

WebCisplatin is known to be substantially excreted by the kidney and is contraindicated in patients with pre-existing renal impairment. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and renal function should be monitored. ADVERSE REACTIONS Nephrotoxicity phim godzilla king of the monstersWebEvaluation of renal function included: serum creatinine, glomerular filtration rate (inulin clearance), effective renal plasma flow (p-aminohippurate clearance), urinary beta 2-microglobulin and N-acetyl-beta-D-glucosaminidase excretion, and renal tomography. The median cumulated dose of cisplatin was 603 +/- 37 mg/m2. phim goodbye my princessWebAbstract. The purpose of this study was to determine long-term renal platinum excretion after chemotherapy with cisplatin. We examined urinary platinum concentrations in 23 … phim good doctorWebOct 4, 2024 · Most sources consider that mothers receiving antineoplastic therapy should not breastfeed, especially with alkylating agents such as cisplatin. [1] Excretion of … phim gonjiam haunted asylumWebSep 15, 2024 · The most common side effects of Cisplatin include: nausea, vomiting (may be severe), diarrhea, temporary hair loss, loss in ability to taste food, hiccups, dry mouth, dark urine, decreased sweating, dry skin, and other signs of dehydration Tell the doctor if you have any side effect that bothers you or that does not go away. phim gold spoonWebCisplatin is an antineoplastic agent that is FDA approved for the treatment of metastatic testicular tumors, metastatic ovarian tumors, and advanced bladder cancer. There is a Black Box Warning for this drug as shown here. Common adverse reactions include anemia, leukopenia, and thrombocytopenia . Adult Indications and Dosage phim golden lifeWebMoreover, SLCs are responsible for the excretion of catabolites and reabsorption phenomena occurring in the kidney . The ... This is the case of vesicular miR-21 that induced cisplatin resistance in oral squamous cell carcinoma by targeting phosphatase and tensin homolog (PTEN) and programmed cell death protein 4 ... phim gone with the wind